Patellar Tendon Healing With Platelet-Rich Plasma: A Prospective randomized controlled trial
Am J Sports Med June 2012 vol. 40 no. 6 1282-1288
Adriano Marques de Almeida,Marco Kawamura Demange,Marcel Faraco Sobrado,Marcelo Bordalo Rodrigues,André Pedrinelli,Arnaldo José Hernandez
Published online before print April 2, 2012, doi:10.1177/0363546512441344
Background: The patellar tendon has limited ability to heal after harvesting its central third. Platelet-rich plasma (PRP) could improve patellar tendon healing.
Hypothesis: Adding PRP to the patellar tendon harvest site would improve donor site healing and improve clinical outcome at 6 months after anterior cruciate ligament (ACL) reconstruction with a patellar tendon graft.
Study Design: Randomized controlled trial; Level of evidence, 1.
Methods: Twenty-seven patients were randomly divided to receive (n = 12) or not receive (n = 15) PRP in the patellar tendon harvest site during ACL reconstruction. The primary outcome was magnetic resonance imaging (MRI) assessment of patellar tendon healing (gap area) after 6 months. Secondary outcomes were questionnaires and isokinetic testing of ACL reconstruction with a patellar tendon graft comparing both groups.
Results: Patellar tendon gap area was significantly smaller in the PRP group (4.9 ± 5.3 mm2; 95% confidence interval [CI], 1.1-8.8) than in the control group (9.4 ± 4.4 mm2; 95% CI, 6.6-12.2; P = .046). Visual analog scale score for pain was lower in the PRP group immediately postoperatively (3.8 ± 1.0; 95% CI, 3.18-4.49) than in the control group (5.1 ± 1.4; 95% CI, 4.24-5.90; P = .02). There were no differences after 6 months in questionnaire and isokinetic testing results comparing both groups.
Conclusion: We showed that PRP had a positive effect on patellar tendon harvest site healing on MRI after 6 months and also reduced pain in the immediate postoperative period. Questionnaire and isokinetic testing results were not different between the groups at 6 months.